Q.What is Calcium D-Glucarate?
A.Calcium D-Glucarate is a supplemental combination of calcium and D-glucaric acid, a natural substance found in fruits, vegetables, and produced in the human body. Acidic fruits like oranges, apples, and grapefruit produce the highest concentrations of glucaric acid.

Q.What are the results of oral supplementation of Calcium D-Glucarate?
A.Studies have shown that oral supplementation of Calcium D- Glucarate inhibits beta-glucuronidase, an enzyme produced in the colon and involved in Phase II liver detoxification. Elevated beta-glucuronidase activity increases the risk for various cancers, particularly breast, prostate, and colon cancers.

Q.Are there any other clinical applications of Calcium D-Glucarate?
A.Calcium D-Glucarate is also effective in the regulation of estrogen metabolism and as a lipid-lowering agent. When Calcium D-Glucarate is exposed to stomach acid, Calcium D-Glucarate is metabolized to form D-Glucaric acid.
D-Glucaric acid is further broken down in the gastrointestinal tract into three compounds: D-Glucaric acid, D-Glucaro-1,4 lactone, and D-Glucaro-6,3 lactone. These compounds are then transported to the blood and various internal organs and excreted in the urine and bile.

Q.What makes Calcium D-Glucarate an excellent detoxification product?

A.Calcium D-Glucarate is effective as a detoxifyier and anti-carcinogenic because of its ability to increase glucuronication and excretion of potentially toxic compounds. During Phase II detoxification, chemical carcinogens, steroid hormones and other lipid-soluble toxins are conjugated with glucuronic acid in the liver (glucuronication), and excreted through the billary tract.

Q.Is Calcium D-Glucarate an essential nutrient?
A.Calcium D- Glucarate is not an essential nutrient so, technically, you cannot have a deficiency. However, it is only produced in small amounts in the human body, so adequate dietary supplementation is important. Diets low in fruits (particularly oranges, apples and grapefruit) and cruciferous vegetables (broccoli, cabbage, and Brussels sprouts) may result in a relative deficiency of Calcium D-Glucarate. Research has shown that low levels of D-Glucaric acid are associated with higher levels of beta-glucuronidase, which increases risk for various cancers.

Q.What type of chemical is Glucaric Acid?
A.Glucaric Acid is a chemical made by the body and also consumed in foods. For dietary supplementation, it is combined with calcium to form Calcium D-Glucarate.

Q.Does Calcium D-Glucarate help with the prevention of some cancers?
A.Because of its strong detoxifying properties, glucaric acid has been promoted for preventing cancer. Calcium D-Glucarate has also been shown to decrease the body's levels of an enzyme associated with breast, colon, and prostate cancers.
Glucaric acid prevents with the reabsorption of estrogen through the gastrointestinal tract. As a result, more estrogen is eliminated from the body and less stays in the blood. High estrogen levels have also been associated with high risk of breast, colon, and prostate cancers.

Q.Can Calcium D-Glucarate improve my immune system and detoxify my body?
A.Optimal metabolism and growth requires a clean internal/chemical environment. The liver is the key organ for detoxification and hundreds of other reactions related to anabolism and catabolism in muscle and connective tissue. The immune system controls tissue repair. Detoxifying the body reduces the load on the liver and immune system,  allowing more of the body’s energy to be directed toward repair of tissue damage, nutrient processing, and muscle growth.